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They thought Ozempic would help them lose weight. It didn't work. |

Behind the huge success of drugs like Ozempic and Wegovy is a lesser-noticed phenomenon: some people don't lose much weight on them.

There is a wide variation in weight loss in these types of drugs, called GLP-1. Doctors say 10% to 15% of people who try them are “non-responders,” usually defined as those who lose less than 5% of their body weight. These patients, doctors say, do not experience enough reduction in appetite to cause significant weight loss.

Researchers are studying why some people lose a lot of weight while others lose little. The answers could provide more clues about weight loss and provide more insight into these drugs, which have transformed the way Americans lose weight.

Doctors believe that some people may be resistant to the drugs as a result of genetic differences. Other possible reasons could include certain medical conditions and medications, how much weight a person lost before taking the medications, and differences in how people metabolize them.


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